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Topics

  • Genome-wide Association Studies and candidate gene analyses

    We perform genome-wide association analyses for both, quantitative traits for different phenotypes and case-control designs for different disease entities. This comprises data management, quality control, state of the art data analysis, replication studies, meta-analyses and pipeline development. The studies are performed in close co-operations with our clinical partners.
  • Molecular Epidemiology

    We design, establish, conduct and analyse observational studies with molecular-genetic focus. Examples are PROGRESS, CAPSyS, LIFE-Adult and LIFE-Heart.
  • Population Genetics

    On the basis of genetic markers, we aim to compare populations by different population genetic means.
  • Integrative Genome Analyses

    We study the relations of different molecular-genetic markers (e.g. SNPs, expression profiles, metabolomics) and (disease) phenotypes. This comprises data management and mapping, high-throughput computations, management of high-dimensional analysis results and systems-biological modelling. As a new and hot topic, we study, develop and apply methods of causal inference regarding relationships of molecular-genetic layers.
  • Comparison and Development of Statistical Methods

    In order to ensure state of the art analyses methods, we are routinely concerned with comparisons and evaluations of newly developed methods or software tools. We also aim to develop own standards regarding different types of analysis.
  • Systems-biology

    In order to improve our understanding of both, physiological processes and pathomechanisms and in order to enable predictions, we aim to construct statistical or continuous mathematical models. Examples are hierarchical modelling of pathways or disease and therapy models based on ordinary differential equations.